Hirotoshi Kakuta: search on Z-Library

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1

Unique “delta lock” structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor

Kazuki Ohno, Yasushi Amano, Hirotoshi Kakuta, Tatsuya Niimi, Shoji Takakura, Masaya Orita, Keiji Miyata, Hitoshi Sakashita, Makoto Takeuchi, Issei Komuro, Jitsuo Higaki, Masatsugu Horiuchi, Shokei Kim

Journal:

Biochemical and Biophysical Research Communications

Year:

2011

Language:

english

File:

PDF, 599 KB

english, 2011

2

Atorvastatin increases hepatic fatty acid beta-oxidation in sucrose-fed rats: comparison with an MTP inhibitor

Toshiyuki Funatsu, Hirotoshi Kakuta, Toshiyuki Takasu, Keiji Miyata

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 166 KB

english, 2002

3

YM-53601, a novel squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in several animal species

Tohru Ugawa, Hirotoshi Kakuta, Hirosh Moritani, Koyo Matsuda, Tsukasa Ishihara, Motoko Yamaguchi, Shin Naganuma, Yuichi Iizumi, Hisataka Shikama

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 163 KB

english, 2000

4

YM-53601, a novel squalene synthase inhibitor, suppresses lipogenic biosynthesis and lipid secretion in rodents

Tohru Ugawa, Hirotoshi Kakuta, Hiroshi Moritani, Osamu Inagaki, Hisataka Shikama

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 147 KB

english, 2003

5

Experimental model of postprandial hypertriglyceridemia in sucrose-fed rats and the effectiveness of atorvastatin in the model

Toshiyuki Funatsu, Hirotoshi Kakuta, Toshiyuki Takasu, Masahiro Noguchi, Masanori Suzuki, Keiji Miyata

Journal:

Year:

2003

Language:

english

File:

PDF, 132 KB

english, 2003

6

Effect of YM-53601, a novel squalene synthase inhibitor, on the clearance rate of plasma LDL and VLDL in hamsters

Tohru Ugawa, Hirotoshi Kakuta, Hiroshi Moritani, Osamu Inagaki

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 149 KB

english, 2002

7

Syntheses and biological evaluation of novel quinuclidine derivatives as squalene synthase inhibitors

Tsukasa Ishihara, Hirotoshi Kakuta, Hiroshi Moritani, Tohru Ugawa, Shuichi Sakamoto, Shin-ichi Tsukamoto, Isao Yanagisawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 340 KB

english, 2003

8

An Angiotensin II (Ang II) Type 1 Receptor Blocker, Telmisartan Protects Against Neurological Deficits and Prolongs Survival in Spontaneously Hypertensive Rats Stroke-Prone (SHR-SP) Infused with Ang II

Kakuta, Hirotoshi, Sudoh, Katsumi, Terai, Kazuhiro, Sasamata, Masao, Yoshida, Takafumi, Yamagishi, Sho-ichi

Journal:

Vascular Disease Prevention

Year:

2007

Language:

english

File:

PDF, 165 KB

english, 2007

9

Syntheses of 3-Ethylidenequinuclidine derivatives as squalene synthase inhibitors. Part 2: enzyme inhibition and effects on plasma lipid levels

Tsukasa Ishihara, Hirotoshi Kakuta, Hiroshi Moritani, Tohru Ugawa, Shuichi Sakamoto, Shin-ichi Tsukamoto, Isao Yanagisawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 321 KB

english, 2003

10

Synthesis and properties of conjugated polymers from 3,6-di(4-chlorophenyl)-3,6-dihydrophthalic acid diethyl ester and application to the photo-sensitizer of a solar cell

Morikawa, Atsushi, Kakuta, Hirotoshi

Journal:

Polymer Journal

Year:

2013

Language:

english

File:

PDF, 870 KB

english, 2013

11

Thermally stabilized transitional alumina prepared by fume pyrolysis of boehmite sols

Takao Ishikawa, Ryuusei Ohashi, Hirotoshi Nakabayashi, Noriyoshi Kakuta, Akifumi Ueno, Akio Furuta

Journal:

Journal of Catalysis

Year:

1992

Language:

english

File:

PDF, 7.37 MB

english, 1992

12

Atorvastatin (Lipitor). A review of its pharmacological and clinical profile.

FUNATSU, Toshiyuki, KAKUTA, Hirotoshi, TANAKA, Hideyuki, ARAI, Yukinori, SUZUKI, Keiko, MIYATA, Keiji

Journal:

Folia Pharmacologica Japonica

Year:

2001

File:

PDF, 1.35 MB

2001

13

Generation of acid sites on TiO2-SnO2 binary oxide prepared from metal alkoxides.

NAKABAYASHI, Hirotoshi, NISHIWAKI, Katsuhiko, KAKUTA, Noriyoshi, UENO, Akifumi

Journal:

NIPPON KAGAKU KAISHI

Year:

1991

File:

PDF, 1.74 MB

1991

14

Synthesis and biological evaluation of novel propylamine derivatives as orally active squalene synthase inhibitors

Tsukasa Ishihara, Hirotoshi Kakuta, Hiroshi Moritani, Tohru Ugawa, Isao Yanagisawa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 420 KB

english, 2004

15

Experimental model of escape phenomenon in hamsters and the effectiveness of YM-53601 in the model

Tohru Ugawa, Hirotoshi Kakuta, Hiroshi Moritani, Hisataka Shikama

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 156 KB

english, 2002

16

Reduction in hepatic non-esterified fatty acid concentration after long-term treatment with atorvastatin lowers hepatic triglyceride synthesis and its secretion in sucrose-fed rats

Toshiyuki Funatsu, Masahide Goto, Hirotoshi Kakuta, Masanori Suzuki, Motoko Ida, Satomi Nishijima, Hideyuki Tanaka, Shuhei Yasuda, Keiji Miyata

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2002

Language:

english

File:

PDF, 440 KB

english, 2002

17

Synthesis and Biological Evaluation of Quinuclidine Derivatives Incorporating Phenothiazine Moieties as Squalene Synthase Inhibitors

Ishihara, Tsukasa, Kakuta, Hirotoshi, Moritani, Hiroshi, Ugawa, Tohru, Yanagisawa, Isao

Journal:

CHEMICAL & PHARMACEUTICAL BULLETIN

Year:

2004

Language:

english

File:

PDF, 234 KB

english, 2004

18

Brain penetration of telmisartan, a unique centrally acting angiotensin II type 1 receptor blocker, studied by PET in conscious rhesus macaques

Akihiro Noda, Hiroshi Fushiki, Yoshihiro Murakami, Hiroshi Sasaki, Sosuke Miyoshi, Hirotoshi Kakuta, Shintaro Nishimura

Journal:

Nuclear Medicine and Biology

Year:

2012

Language:

english

File:

PDF, 301 KB

english, 2012

19

Pharmacological and clinical profile of bixalomer (Kiklin^|^#174; capsules): a new therapeutic agent for hyperphosphatemia

Taniguchi, Keiichi, Kakuta, Hirotoshi, Tomura, Yuichi, Kaku, Seiji, Uchida, Wataru

Journal:

Folia Pharmacologica Japonica

Year:

2013

File:

PDF, 715 KB

2013

20

Synthesis and Biological Evaluation of Quinuclidine Derivatives Incorporating Phenothiazine Moieties as Squalene Synthase Inhibitors.

Tsukasa Ishihara, Hirotoshi Kakuta, Hiroshi Moritani, Tohru Ugawa, Isao Yanagisawa

Journal:

Year:

2005

File:

PDF, 13 KB

2005

21

Generation of acid sites on finely divided TiO2

Katsuhiko Nishiwaki, Noriyoshi Kakuta, Akifumi Ueno, Hirotoshi Nakabayashi

Journal:

Journal of Catalysis

Year:

1989

Language:

english

File:

PDF, 293 KB

english, 1989

22

Strong Acid Sites Created on Small–Sized Anatase

Nakabayashi, Hirotoshi, Kakuta, Noriyoshi, Ueno, Akifumi

Journal:

Bulletin of the Chemical Society of Japan

Year:

1991

File:

PDF, 663 KB

1991

23

Assembly of Lipoprotein (a) in Transgenic Rabbits Expressing Human Apolipoprotein (a)

Jianglin Fan, Masahiro Araki, Lihua Wu, Mireille Challah, Hiroaki Shimoyamada, Richard M. Lawn, Hirotoshi Kakuta, Hisakata Shikama, Teruo Watanabe

Journal:

Biochemical and Biophysical Research Communications

Year:

1999

Language:

english

File:

PDF, 404 KB

english, 1999

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